Ifi27^tm1Npm
Targeted Allele Detail

Summary

• Symbol: Ifi27^tm1Npm
• Name: interferon, alpha-inducible protein 27; targeted mutation 1, Nikolina Papac-Milicevic
• MGI ID: MGI:5582315
• Gene: Ifi27 Location: Chr12:103400470-103406498 bp, + strand Genetic Position: Chr12, 52.93 cM
• Alliance: Ifi27^tm1Npm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212520
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 1 through 4. RT-PCR confirmed the absence of transcript expression in the spleen. (J:212520)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifi27 Mutation: 12 strains or lines available

References

• Original: J:212520 Papac-Milicevic N, et al., The interferon stimulated gene 12 inactivates vasculoprotective functions of NR4A nuclear receptors. Circ Res. 2012 Apr 13;110(8):e50-63
• All: 3 reference(s)