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Wnt10btm1e.1(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Wnt10btm1e.1(KOMP)Wtsi
Name: wingless-type MMTV integration site family, member 10B; targeted mutation 1e.1, Wellcome Trust Sanger Institute
MGI ID: MGI:5582422
Gene: Wnt10b  Location: Chr15:98668593-98676031 bp, - strand  Genetic Position: Chr15, 54.65 cM
Alliance: Wnt10btm1e.1(KOMP)Wtsi page
IMPC: Wnt10b gene page
Mutation
origin
Mutant Cell Line:  EPD0314_2_A09
Germline Transmission:  Earliest citation of germline transmission: J:204739
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsCre-mediated excision of the parental Wnt10btm1e(KOMP)Wtsi allele resulted in the removal of the promoter-driven neomycin selection cassette leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
EPD0314_2_A09
Phenotypes:
Affected Systems
show or hide all annotated terms Sex:
Source:
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IMPC - UCD
IMPC - UCD
digestive/alimentary system
abnormal cecum morphology
nervous system
abnormal brain morphology
hydrocephaly
skeleton
decreased bone mineral content
decreased bone mineral density
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Wnt10b Mutation:  19 strains or lines available
References
Original:  J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory