Wnt10b^{tm1e.1(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Wnt10b^{tm1e.1(KOMP)Wtsi}
• Name: wingless-type MMTV integration site family, member 10B; targeted mutation 1e.1, Wellcome Trust Sanger Institute
• MGI ID: MGI:5582422
• Gene: Wnt10b Location: Chr15:98668593-98676031 bp, - strand Genetic Position: Chr15, 54.65 cM
• Alliance: Wnt10b^{tm1e.1(KOMP)Wtsi} page
• IMPC: Wnt10b gene page

Mutation origin

• Mutant Cell Line: EPD0314_2_A09
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: Cre-mediated excision of the parental Wnt10b^{tm1e(KOMP)Wtsi} allele resulted in the removal of the promoter-driven neomycin selection cassette leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Wnt10b^tm1e.1(KOMP)Wtsi/Wnt10b^tm1e.1(KOMP)Wtsi	C57BL/6N-Wnt10b^tm1e.1(KOMP)Wtsi/Ucd	EPD0314_2_A09

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms Sex:
Source:	IMPC - UCD	IMPC - UCD
digestive/alimentary system	√	√
abnormal cecum morphology	√	√
nervous system		√
abnormal brain morphology		√
hydrocephaly		√
skeleton	√	√
decreased bone mineral content	√	√
decreased bone mineral density	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wnt10b Mutation: 19 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 5 reference(s)