Tg(Krt5-Tnfr1)#Rsab
Transgene Detail

Summary

• Symbol: Tg(Krt5-Tnfr1)#Rsab
• Name: transgene insertion, Robert Sabat
• MGI ID: MGI:5582482
• Synonyms: K5-Tnfr1
• Transgene: Tg(Krt5-Tnfr1)#Rsab Location: unknown
• Alliance: Tg(Krt5-Tnfr1)#Rsab page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Krt5-Tnfr1)#Rsab expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tnfrsf1a (MGI:1314884)

• Mutation details: The promoter drives epidermal keratonocyte-specific expression of the inserted sequence. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:208995)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Tg(KRT5-Nfkbia*)3Rto/0 Tg(Krt5-Tnfr1)#Rsab/0 Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * C57BL/6 * CBA

Phenotypes:

Affected Systems	cx1
show or hide all annotated terms
immune system	√
skin inflammation	√
integument	√
skin inflammation	√
epidermal hyperplasia	√
mortality/aging	√
postnatal lethality, incomplete penetrance	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:208995 Kumari S, et al., Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. Immunity. 2013 Nov 14;39(5):899-911
• All: 1 reference(s)