Tg(H2-K-IL6)2Srj
Transgene Detail

Summary

• Symbol: Tg(H2-K-IL6)2Srj
• Name: transgene insertion 2, Stefan Rose-John
• MGI ID: MGI:5582513
• Synonyms: vIL-6tg2
• Transgene: Tg(H2-K-IL6)2Srj Location: unknown
• Alliance: Tg(H2-K-IL6)2Srj page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The MHC class I promoter H2K drives the expression of the HHV-8 viral IL6 with a C-terminal MYC tag predominantly in hematopoietic organs and lymphocytes. Two lines were established, 1 and 2. (J:185153)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: Multicentric Castleman Disease, Plasma-cell type J:185153

References

• Original: J:185153 Suthaus J, et al., HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice. Blood. 2012 May 31;119(22):5173-81
• All: 2 reference(s)