Shcbp1tm1c(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Shcbp1tm1c(EUCOMM)Wtsi |
Name: |
Shc SH2-domain binding protein 1; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:5582589 |
Synonyms: |
Shcbp1FL |
Gene: |
Shcbp1 Location: Chr8:4785976-4829549 bp, - strand Genetic Position: Chr8, 2.09 cM, cytoband A1.2
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Alliance: |
Shcbp1tm1c(EUCOMM)Wtsi page
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IMPC: |
Shcbp1 gene page |
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Mutant Cell Line: |
EPD0592_2_A06 |
Germline Transmission: |
Earliest citation of germline transmission:
J:212898
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 4798418 of Chromosome 8 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 4800268. The critical exon(s) are thus flanked by loxP sites. The lacZ and neomycin segments were excised with germline Actin-Flp recombinase, leaving exons 4 and 6 flanked by loxP sites. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
(J:155845, J:212898)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:212898 Buckley MW, et al., Unexpected Phenotype of Mice Lacking Shcbp1, a Protein Induced during T Cell Proliferation. PLoS One. 2014;9(8):e105576 |
All: |
2 reference(s) |
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