Tnf^M2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tnf^M2Btlr
• Name: tumor necrosis factor; mutation 2, Bruce Beutler
• MGI ID: MGI:5582740
• Synonyms: Dome
• Gene: Tnf Location: Chr17:35418357-35420983 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Tnf^M2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Translocation
• Mutation details: ENU mutagenesis induced a T to C transition at base pair 35,201,674 (v38) on chromosome 17, or base pair 334 in the GenBank genomic region NC_000083. The mutation corresponds to residue 334 in the mRNA sequence NM_013693 within exon 4 of 6 total exons. The mutation results in an isoleucine (I) to threonine (T) substitution at position 56 (I56T). (J:213047)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnf Mutation: 48 strains or lines available

References

• Original: J:213047 Zhang Z, et al., Mutagenetix entry for Dome. MGI Direct Data Submission. 2014
• All: 1 reference(s)