Tyrp1^b-2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tyrp1^b-2Btlr
• Name: tyrosinase-related protein 1; brown 2 Bruce Beutler
• MGI ID: MGI:5582741
• Synonyms: ca-los
• Gene: Tyrp1 Location: Chr4:80752360-80769956 bp, + strand Genetic Position: Chr4, 37.89 cM
• Alliance: Tyrp1^b-2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a C to T transition at base pair 80,844,868 (v38) on chromosome 4, or base pair 10,661 in the GenBank genomic region NC_000070. The mutation corresponds to residue 1,280 in the mRNA sequence NM_031202 within exon 5 of 8 total exons. The mutated nucleotide is indicated in results in the conversion of glutamine 331 to a stop codon (Q331*). (J:213048)
• Inheritance: Not Specified

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Tyrp1^b-2Btlr/Tyrp1^b-2Btlr	C57BL/6J-Tyrp1^b-2Btlr

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
integument	√
diluted coat color	√
pigmentation	√
diluted coat color	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tyrp1 Mutation: 162 strains or lines available

References

• Original: J:213048 Purrington T, et al., Mutagenetix entry for ca-los. MGI Direct Data Submission. 2014
• All: 1 reference(s)