Pik3cd^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Pik3cd^m1Btlr
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; mutation 1, Bruce Beutler
• MGI ID: MGI:5582742
• Synonyms: stinger
• Gene: Pik3cd Location: Chr4:149733625-149787023 bp, - strand Genetic Position: Chr4, 80.15 cM
• Alliance: Pik3cd^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to G transversion at base pair 149,657,319 (v38) on chromosome 4, or base pair 68,648 in the GenBank genomic region NC_000070. The mutation corresponds to residue 1447 in the mRNA sequence NM_001029837 within exon 8 of 23 total exons. The mutation results in a leucine (L) to arginine (R) substitution at position 390 (L390R). (J:213049)
• Inheritance: Recessive

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Pik3cd^m1Btlr/Pik3cd^m1Btlr	C57BL/6J-Pik3cd^m1Btlr

Phenotypes:

Affected Systems	hm1
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immune system	√
abnormal humoral immune response	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pik3cd Mutation: 45 strains or lines available

References

• Original: J:213049 Arnold C, et al., Mutagenetix entry for stinger. MGI Direct Data Submission. 2014
• All: 1 reference(s)