F8^tm1.1Rmnt
Targeted Allele Detail

Summary

• Symbol: F8^tm1.1Rmnt
• Name: coagulation factor VIII; targeted mutation 1.1, Robert Montgomery
• MGI ID: MGI:5582808
• Synonyms: F8^F
• Gene: F8 Location: ChrX:74216321-74426221 bp, - strand Genetic Position: ChrX, 38.17 cM, cytoband A7-B
• Alliance: F8^tm1.1Rmnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212401
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 17 and 18 and FRT-flanked neo cassette were flanked by two loxP sites. FLP-mediated recombinase removed the neo cassette, leaving exons 17 and 18 floxed. (J:212401)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any F8 Mutation: 25 strains or lines available

References

• Original: J:212401 Fahs SA, et al., A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII. Blood. 2014 Jun 12;123(24):3706-13
• All: 2 reference(s)