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Clec4ntm1.2Mgne
Targeted Allele Detail
Summary
Symbol: Clec4ntm1.2Mgne
Name: C-type lectin domain family 4, member n; targeted mutation 1.2, Mihai G Netea
MGI ID: MGI:5582826
Gene: Clec4n  Location: Chr6:123206802-123223980 bp, + strand  Genetic Position: Chr6, 58.3 cM, cytoband F3
Alliance: Clec4ntm1.2Mgne page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:209284
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Inversion
 
Mutation detailsA lox66 was inserted upstream of exon 2. An inverted STOP element and lox71 site was inserted downstream of exon 2. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted between exon 2 and 3. Cre-mediated recombination restores the orientation of the STOP element and inverts exon 2. (J:209284)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clec4n Mutation:  27 strains or lines available
References
Original:  J:209284 Ifrim DC, et al., Role of Dectin-2 for host defense against systemic infection with Candida glabrata. Infect Immun. 2014 Mar;82(3):1064-73
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory