Gde1^tm1Crv
Targeted Allele Detail

Summary

• Symbol: Gde1^tm1Crv
• Name: glycerophosphodiester phosphodiesterase 1; targeted mutation 1, Benjamin F Cravatt
• MGI ID: MGI:5583864
• Gene: Gde1 Location: Chr7:118287781-118304961 bp, - strand Genetic Position: Chr7, 63.52 cM, cytoband F3
• Alliance: Gde1^tm1Crv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213193
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 2. Western blot analysis confirmed the absence of protein expression in the brain. (J:213193)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gde1 Mutation: 21 strains or lines available

References

• Original: J:213193 Simon GM, et al., Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo. Mol Biosyst. 2010 Aug;6(8):1411-8
• All: 2 reference(s)