Chat^tm1Mlt
Targeted Allele Detail

Summary

• Symbol: Chat^tm1Mlt
• Name: choline O-acetyltransferase; targeted mutation 1, Jacques Mallet
• MGI ID: MGI:5583868
• Synonyms: Chat^lox
• Gene: Chat Location: Chr14:32130160-32187866 bp, - strand Genetic Position: Chr14, 19.4 cM
• Alliance: Chat^tm1Mlt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212048
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP-flanked neomycin cassette was inserted upstream of exon 8 and a third loxP sequence in intron 8. Cre mediated recombinase removed the neo cassette. Removal of exon 8 will result in frame-shift mutation with truncated protein. (J:212048)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chat Mutation: 58 strains or lines available

References

• Original: J:212048 Lecomte MJ, et al., Selective disruption of acetylcholine synthesis in subsets of motor neurons: a new model of late-onset motor neuron disease. Neurobiol Dis. 2014 May;65:102-11
• All: 3 reference(s)