Secisbp2^{tm1d(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Secisbp2^{tm1d(EUCOMM)Wtsi}
• Name: SECIS binding protein 2; targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:5583886
• Synonyms: Secisbp2^delta5
• Gene: Secisbp2 Location: Chr13:51805733-51838080 bp, + strand Genetic Position: Chr13, 26.12 cM, cytoband B1
• Alliance: Secisbp2^{tm1d(EUCOMM)Wtsi} page
• IMPC: Secisbp2 gene page

Mutation origin

• Mutant Cell Line: EPD0052_2_C03
• Germline Transmission: Earliest citation of germline transmission: J:213080
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_gt1
• Mutation details: The L1L2_gt1 cassette was inserted at position 51810446 of Chromosome 13 upstream of the critical exon 5 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon 5 at position 51811429. The critical exon 5 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Cre-mediated recombination removed exon 5. (J:213080)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Secisbp2 Mutation: 56 strains or lines available

References

• Original: J:213080 Seeher S, et al., Secisbp2 is essential for embryonic development and enhances selenoprotein expression. Antioxid Redox Signal. 2014 Aug 20;21(6):835-49
• All: 1 reference(s)