Ninj1^tm1Gto
Targeted Allele Detail

Summary

• Symbol: Ninj1^tm1Gto
• Name: ninjurin 1; targeted mutation 1, Goo Taeg Oh
• MGI ID: MGI:5583960
• Synonyms: Ninj1TM1GTO
• Gene: Ninj1 Location: Chr13:49341005-49349727 bp, + strand Genetic Position: Chr13, 25.14 cM
• Alliance: Ninj1^tm1Gto page

Ninj1^tm1Gto/Ninj1^tm1Gto mice have reduced leukocyte recruitment into the spinal cord injury with experimental autoimmune encephalomyelitis

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209516
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neomycin resistance cassette replaced exon 1. Western blot analysis confirmed the absence of protein expression in the brain, liver, kidney and spinal cord. (J:209516, J:212152)

Generation of the Ninj1^tm1Gto allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ninj1 Mutation: 17 strains or lines available

References

• Original: J:209516 Ahn BJ, et al., Ninjurin1 deficiency attenuates susceptibility of experimental autoimmune encephalomyelitis in mice. J Biol Chem. 2014 Feb 7;289(6):3328-38
• All: 10 reference(s)