Del(XArmcx5-Nxf3)3Jw
Targeted Allele Detail

Summary

• Symbol: Del(XArmcx5-Nxf3)3Jw
• Name: deletion, Chr X, Jeremy Wang 3
• MGI ID: MGI:5584172
• Synonyms: DelC, Del(XArmcx5-Nxf3)1Jw
• Gene: Del(XArmcx5-Nxf3)3Jw Location: unknown Genetic Position: ChrX, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210663
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(XArmcx5-Nxf3)3Jw involves 2 genes/genome features (Armcx5, Nxf3) View all
• Mutation details: Nxf3^tm1.1Jw/Y ES cells were electroporated with the pUP108 vector used to generate the Igs8^tm1Jw allele which replaces a 5.6 kb intergenic region between Tmsb15a and Armcx5 with a floxed PGK-neo selection cassette, producing a targeted conditional allele with four loxP sites. Mice carrying this floxed allele were crossed with Actb-Cre mice to delete a 350 kb region on mouse chromosome X between Armcx5 and Nxf3. (J:210663)

Disease models

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(XArmcx5-Nxf3)3Jw Mutation: 0 strains or lines available

References

• Original: J:210663 Zhou J, et al., Respiratory failure, cleft palate and epilepsy in the mouse model of human Xq22.1 deletion syndrome. Hum Mol Genet. 2014 Jul 15;23(14):3823-9
• All: 1 reference(s)