Gng8^tm1(tTA)Rtir
Targeted Allele Detail

Summary

• Symbol: Gng8^tm1(tTA)Rtir
• Name: guanine nucleotide binding protein (G protein), gamma 8; targeted mutation 1, Roberto Tirindelli
• MGI ID: MGI:5584308
• Synonyms: Ggamma8^-
• Gene: Gng8 Location: Chr7:16625711-16629361 bp, + strand Genetic Position: Chr7, 9.15 cM
• Alliance: Gng8^tm1(tTA)Rtir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212780
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Transactivator)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding sequence was replaced with a tetracycline transactivator (tTA) and neomycin resistance cassette. (J:212780)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gng8 Mutation: 10 strains or lines available

References

• Original: J:212780 Montani G, et al., Aggressive behaviour and physiological responses to pheromones are strongly impaired in mice deficient for the olfactory G-protein -subunit G8. J Physiol. 2013 Aug 15;591(Pt 16):3949-62
• All: 1 reference(s)