Tg(Ins2-Mir184)4Mnpy
Transgene Detail

Summary

• Symbol: Tg(Ins2-Mir184)4Mnpy
• Name: transgene insertion 4, Matthew N Poy
• MGI ID: MGI:5585172
• Synonyms: Tg-04
• Transgene: Tg(Ins2-Mir184)4Mnpy Location: unknown
• Alliance: Tg(Ins2-Mir184)4Mnpy page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-Mir184)4Mnpy expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mir184 (MGI:2676848)

• Tg(Ins2-Mir184)4Mnpy expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: The rat promoter drives beta cell-specific expression of the microRNA. Lines 4, 32 and 96 were generated. Lines 4 and 32 (high expressors) exhibit a 100-fold increase in expression. Line 96 (low expressor) exhibits a 5-fold increase in expression. (J:210552)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:210552 Tattikota SG, et al., Argonaute2 mediates compensatory expansion of the pancreatic beta cell. Cell Metab. 2014 Jan 7;19(1):122-34
• All: 1 reference(s)