Ptbp1^tm1Nobu
Targeted Allele Detail

Summary

• Symbol: Ptbp1^tm1Nobu
• Name: polypyrimidine tract binding protein 1; targeted mutation 1, Nobuaki Yoshida
• MGI ID: MGI:5585398
• Gene: Ptbp1 Location: Chr10:79690502-79700269 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Ptbp1^tm1Nobu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213626
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 1.9 kb of the gene, including the promoter and transcription start site. (J:213626)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptbp1 Mutation: 36 strains or lines available

References

• Original: J:213626 Shibayama M, et al., Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation. FEBS J. 2009 Nov;276(22):6658-68
• All: 2 reference(s)