Ptbp1^tm2Nobu
Targeted Allele Detail

Summary

• Symbol: Ptbp1^tm2Nobu
• Name: polypyrimidine tract binding protein 1; targeted mutation 2, Nobuaki Yoshida
• MGI ID: MGI:5585399
• Synonyms: Ptb^floxed, Ptb^flox-hyg
• Gene: Ptbp1 Location: Chr10:79690502-79700269 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Ptbp1^tm2Nobu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213479
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed hyogrmycin resistance cassette was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 1. (J:213626)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptbp1 Mutation: 36 strains or lines available

References

• Original: J:213479 Shibasaki T, et al., PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus. Cereb Cortex. 2013 Aug;23(8):1824-35
• All: 5 reference(s)