Angpt1^tm1.1Yona
Targeted Allele Detail

Summary

• Symbol: Angpt1^tm1.1Yona
• Name: angiopoietin 1; targeted mutation 1.1, Yoshikazu Nakaoka
• MGI ID: MGI:5585457
• Synonyms: Ang1^fl, Ang1^flox
• Gene: Angpt1 Location: Chr15:42288119-42540373 bp, - strand Genetic Position: Chr15, 16.69 cM
• Alliance: Angpt1^tm1.1Yona page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213456
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 1 was floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of exon 1. (J:213456, J:288357)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Angpt1 Mutation: 35 strains or lines available

References

• Original: J:213456 Lee J, et al., Angiopoietin-1 guides directional angiogenesis through integrin alphavbeta5 signaling for recovery of ischemic retinopathy. Sci Transl Med. 2013 Sep 18;5(203):203ra127
• All: 10 reference(s)