Sucla2^{Gt(SAbetageo)1Bhg}
Gene trapped Allele Detail

Summary

• Symbol: Sucla2^{Gt(SAbetageo)1Bhg}
• Name: succinate-Coenzyme A ligase, ADP-forming, beta subunit; gene trap 1, Brett H Graham
• MGI ID: MGI:5585619
• Synonyms: Sucla2^SAbeta-geo
• Gene: Sucla2 Location: Chr14:73790226-73833584 bp, + strand Genetic Position: Chr14, 39.06 cM, cytoband D2
• Alliance: Sucla2^{Gt(SAbetageo)1Bhg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213453
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Gene trapped (Hypomorph, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The beta-geo containing gene trap inserted into intron 4. RT-PCR confirmed low level expression of the wild-type transcript. (J:213453)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sucla2 Mutation: 55 strains or lines available

References

• Original: J:213453 Donti TR, et al., Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion. Dis Model Mech. 2014 Feb;7(2):271-80
• All: 1 reference(s)