Kmt2d^tm1.1Kaig
Targeted Allele Detail

Summary

• Symbol: Kmt2d^tm1.1Kaig
• Name: lysine (K)-specific methyltransferase 2D; targeted mutation 1.1, Kai Ge
• MGI ID: MGI:5585624
• Synonyms: Mll4^f
• Gene: Kmt2d Location: Chr15:98729550-98769085 bp, - strand
• Alliance: Kmt2d^tm1.1Kaig page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207891
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 16. An FRT-flanked neomycin resistance cassette with a 3 loxP site was inserted downstream of exon 19. Flp-mediated recombination removed the selection cassette and left exons 16 through 19 floxed. (J:207891)

Expression

In Mice Carrying this Mutation:	36 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kmt2d Mutation: 169 strains or lines available

References

• Original: J:207891 Lee JE, et al., H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation. Elife. 2013;2:e01503
• All: 14 reference(s)