Tfam^tm1.1Ncdl
Targeted Allele Detail

Summary

• Symbol: Tfam^tm1.1Ncdl
• Name: transcription factor A, mitochondrial; targeted mutation 1.1, Navdeep Chandel
• MGI ID: MGI:5586702
• Synonyms: TFAM^fl
• Gene: Tfam Location: Chr10:71061294-71074110 bp, - strand Genetic Position: Chr10, 36.83 cM, cytoband B5
• Alliance: Tfam^tm1.1Ncdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213840
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 6, and a FRT-flanked neomycin resistance (neo) cassette followed by a single loxP site downstream of exon 7 of the gene. Flp mediated recombination removed the neomycin cassette. (J:213840)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tfam Mutation: 14 strains or lines available

References

• Original: J:213840 Hamanaka RB, et al., Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development. Sci Signal. 2013 Feb 5;6(261):ra8
• All: 27 reference(s)