Gt(ROSA)26Sor^{tm1(Sirt1)Ktm}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Sirt1)Ktm}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Tadahiro Kitamura
• MGI ID: MGI:5586718
• Synonyms: Rosa26^Sirt1-WT
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Sirt1)Ktm} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209418
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Sirt1)Ktm} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Sirt1 (MGI:2135607)

• Mutation details: A targeting construct introduced into the locus a splice acceptor, floxed neomycin resistance/STOP cassette and cDNA. (J:209418)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:209418 Sasaki T, et al., Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice. Diabetologia. 2014 Apr;57(4):819-31
• All: 2 reference(s)