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Gt(ROSA)26Sortm2(Sirt1)Ktm
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm2(Sirt1)Ktm
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Tadahiro Kitamura
MGI ID: MGI:5586719
Synonyms: Rosa26Sirt1-H355Y
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm2(Sirt1)Ktm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:209418
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA targeting construct introduced into the locus a splice acceptor, floxed neomycin resistance/STOP cassette and cDNA with nucleotide substitution(s) result(s) in the amino acid substitution of tyrosine for histidine at position 355 (H355Y). This mutation is predicted to generate an enzyme dead protein. (J:209418)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  992 strains or lines available
References
Original:  J:209418 Sasaki T, et al., Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice. Diabetologia. 2014 Apr;57(4):819-31
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory