Gt(ROSA)26Sortm2(Sirt1)Ktm
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm2(Sirt1)Ktm |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Tadahiro Kitamura |
MGI ID: |
MGI:5586719 |
Synonyms: |
Rosa26Sirt1-H355Y |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm2(Sirt1)Ktm page
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Germline Transmission: |
Earliest citation of germline transmission:
J:209418
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, Inserted expressed sequence) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: A targeting construct introduced into the locus a splice acceptor, floxed neomycin resistance/STOP cassette and cDNA with nucleotide substitution(s) result(s) in the amino acid substitution of tyrosine for histidine at position 355 (H355Y). This mutation is predicted to generate an enzyme dead protein.
(J:209418)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
992 strains or lines available
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Original: |
J:209418 Sasaki T, et al., Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice. Diabetologia. 2014 Apr;57(4):819-31 |
All: |
1 reference(s) |
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