Gt(ROSA)26Sor^{tm2(Sirt1)Ktm}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(Sirt1)Ktm}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Tadahiro Kitamura
• MGI ID: MGI:5586719
• Synonyms: Rosa26^Sirt1-H355Y
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(Sirt1)Ktm} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209418
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A targeting construct introduced into the locus a splice acceptor, floxed neomycin resistance/STOP cassette and cDNA with nucleotide substitution(s) result(s) in the amino acid substitution of tyrosine for histidine at position 355 (H355Y). This mutation is predicted to generate an enzyme dead protein. (J:209418)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:209418 Sasaki T, et al., Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice. Diabetologia. 2014 Apr;57(4):819-31
• All: 1 reference(s)