Gt(ROSA)26Sor^{tm2(ITK/Syk)Hjum}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(ITK/Syk)Hjum}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Hassan Jumaa
• MGI ID: MGI:5586728
• Synonyms: ROSA26-ITK-Syk
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(ITK/Syk)Hjum} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207306
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(ITK/Syk)Hjum} expresses 2 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ITK (3702)

  Itk	(MGI:96621)

  human

  SYK (6850)

  Syk	(MGI:99515)

• Mutation details: The targeting construct introduced into the locus a splice acceptor, loxP site, FRT site, neomycin resistance cassette, FRT site, STOP sequence, loxP site and fusion of the human cDNAs for ITK and SYK. This fusion is found in peripheral T cell lymphomas (PTCLs) patients harboring the t(5;9)(q33;q22) translocation. (J:207306)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:207306 Bach MP, et al., Premature terminal differentiation protects from deregulated lymphocyte activation by ITK-Syk. J Immunol. 2014 Feb 1;192(3):1024-33
• All: 1 reference(s)