Cd46^tm1Atk
Targeted Allele Detail

Summary

• Symbol: Cd46^tm1Atk
• Name: CD46 antigen, complement regulatory protein; targeted mutation 1, John P Atkinson
• MGI ID: MGI:5586970
• Gene: Cd46 Location: Chr1:194719134-194774557 bp, - strand Genetic Position: Chr1, 98.41 cM
• Alliance: Cd46^tm1Atk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213630
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The complement control protein repeat 1 (CCP 1) and almost all of the CCP 2a sequence of the Cd46 gene was replaced with a Neo cassette. Immunohistochemistry confirmed absence of protein in the epididymis. RT-PCR confirmed absence of mRNA in the eye and testis. (J:213630)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd46 Mutation: 39 strains or lines available

References

• Original: J:213630 Lyzogubov V, et al., Complement regulatory protein CD46 protects against choroidal neovascularization in mice. Am J Pathol. 2014 Sep;184(9):2537-48
• All: 3 reference(s)