Casq2^tm2.1Sgp
Targeted Allele Detail

Summary

• Symbol: Casq2^tm2.1Sgp
• Name: calsequestrin 2; targeted mutation 2.1, Silvia G Priori
• MGI ID: MGI:5587007
• Gene: Casq2 Location: Chr3:101993731-102053830 bp, + strand Genetic Position: Chr3, 44.3 cM, cytoband F3
• Alliance: Casq2^tm2.1Sgp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212671
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was deleted. A loxP site was inserted downstream of the deleted exon. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of the loxP site. (J:212671)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casq2 Mutation: 34 strains or lines available

References

• Original: J:212671 Denegri M, et al., Viral gene transfer rescues arrhythmogenic phenotype and ultrastructural abnormalities in adult calsequestrin-null mice with inherited arrhythmias. Circ Res. 2012 Mar 2;110(5):663-8
• All: 2 reference(s)