Pmpcb^{tm1b(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Pmpcb^{tm1b(EUCOMM)Hmgu}
• Name: peptidase (mitochondrial processing) beta; targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:5587049
• Synonyms: Pmpcb^-
• Gene: Pmpcb Location: Chr5:21942158-21962150 bp, + strand Genetic Position: Chr5, 9.97 cM, cytoband A3
• Alliance: Pmpcb^{tm1b(EUCOMM)Hmgu} page
• IMPC: Pmpcb gene page

Pmpcb^{tm1b(EUCOMM)Hmgu}/Pmpcb^{tm1b(EUCOMM)Hmgu} mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos at E3.5 appear as blastocysts, hatch from the zona pellucida, and form normal outgrowths in culture with very compact inner cell mass.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: HEPD0778_6_A10
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: Cre-mediated excision of the parental Pmpcb^{tm1a(EUCOMM)Hmgu} allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Expression

In Mice Carrying this Mutation:

47 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pmpcb Mutation: 29 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 5 reference(s)