Ncor1^tm1.1Anh
Targeted Allele Detail

Summary

• Symbol: Ncor1^tm1.1Anh
• Name: nuclear receptor co-repressor 1; targeted mutation 1.1, Anthony N Hollenberg
• MGI ID: MGI:5587819
• Synonyms: NCoR^deltaID
• Gene: Ncor1 Location: Chr11:62207132-62348200 bp, - strand Genetic Position: Chr11, 38.08 cM, cytoband B2
• Alliance: Ncor1^tm1.1Anh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213990
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 38 and an FRT flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 41. Flp-mediated recombination removed the selection cassette and left exons 38 through 41 floxed. Cre-mediated recombination removed exons 38 through 41, encoding two of the three receptor interacting domains (N2 and N3). (J:213990)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncor1 Mutation: 396 strains or lines available

References

• Original: J:213990 Astapova I, et al., The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axis. Mol Endocrinol. 2011 Feb;25(2):212-24
• All: 4 reference(s)