Hormad1^tm1Kura
Targeted Allele Detail

Summary

• Symbol: Hormad1^tm1Kura
• Name: HORMA domain containing 1; targeted mutation 1, Hiroki Kurahashi
• MGI ID: MGI:5587823
• Gene: Hormad1 Location: Chr3:95466988-95494982 bp, + strand Genetic Position: Chr3, 40.74 cM, cytoband F2
• Alliance: Hormad1^tm1Kura page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213984
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced exons 1 through 3. Western blot analysis confirmed the absence of protein expression in E12.5 testis. (J:213984)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hormad1 Mutation: 32 strains or lines available

References

• Original: J:213984 Kogo H, et al., HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes. Genes Cells. 2012 Jun;17(6):439-54
• All: 2 reference(s)