Tg(tetO-Aimp1)29872Mcla
Transgene Detail

Summary

• Symbol: Tg(tetO-Aimp1)29872Mcla
• Name: transgene insertion 29872, Matthias Clauss
• MGI ID: MGI:5587972
• Synonyms: EMAPII responder
• Transgene: Tg(tetO-Aimp1)29872Mcla Location: unknown
• Alliance: Tg(tetO-Aimp1)29872Mcla page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-Aimp1)29872Mcla expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Aimp1 (MGI:102774)

• Mutation details: The transgenic construct contains Aimp1 sequence, derived from Methylcholanthrene A (Meth A)-transformed mouse fibrosarcoma cells and encoding mature secreted EMAPII protein, fused to an IFN-beta signal peptide sequence, under the control of the tetO, tetracycline-responsive regulatory element (seven copies of the 42-bp tet operator sequence placed between two minimal CMV enhancer-less promoters). (J:173904)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:173904 Clauss M, et al., Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke-induced emphysema in mice. J Clin Invest. 2011 Jun 1;121(6):2470-9
• All: 1 reference(s)