Tg(Gpr151-cre)#Ito
Transgene Detail

Summary

• Symbol: Tg(Gpr151-cre)#Ito
• Name: transgene insertion, Shigeyoshi Itohara
• MGI ID: MGI:5587996
• Synonyms: Gpr151-Cre
• Transgene: Tg(Gpr151-cre)#Ito Location: unknown
• Alliance: Tg(Gpr151-cre)#Ito page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Gpr151-cre)#Ito expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Gpr151

• Mutation details: BAC clone MSMg01-81G4 was used to generate the transgene that drives expression of a nuclear localization sequence (NLS), cre and polyadenylation sequence cassette. The pound symbol (#) is used when no line is specified and/or lines are pooled (J:214076)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gpr151 (species not specified) Summary of all recombinase alleles driven by Gpr151. Comparative matrix view of recombinase activities
User Notes:	Additional information submitted by the research community Additional information submitted by the research community From Dr. Jessie Benedict: We acquired the mice from frozen embryos through Riken (RBRC10728). In our breeding colony the Gpr151-cre mice had low litter survival rates, often with only 2-3 pups making it to weaning. The pups that did make it to weaning were chronically small at weaning age (under 9g and thus unable to depress the water lixit on their own). In a small pilot experiment, our cre-negative control animals (n=3) showed depressed maternal behavior compared to wildtype C57BL/6 WT mice. Given the issues with pup survival and size in the colony, we suspect a maternal behavior deficit may have been more widespread in the line, or at least in the mice we had.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:214076 Kobayashi Y, et al., Genetic dissection of medial habenula-interpeduncular nucleus pathway function in mice. Front Behav Neurosci. 2013;7:17
• All: 3 reference(s)