Tg(Tek-Tnf*)5382Mcla
Transgene Detail

Summary

• Symbol: Tg(Tek-Tnf*)5382Mcla
• Name: transgene insertion 5382, Matthias Claus
• MGI ID: MGI:5588000
• Synonyms: Tie2-tmTNF
• Transgene: Tg(Tek-Tnf*)5382Mcla Location: unknown
• Alliance: Tg(Tek-Tnf*)5382Mcla page

Transgene origin

• Strain of Origin: C57BL/6 x C3H/He

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tek-Tnf*)5382Mcla expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tnf (MGI:104798)

• Mutation details: The transgenic construct contains cDNA from an uncleavable mutant transmembrane form of the mouse tumor necrosis factor, mTNF1-9,K(11)E, a 570 bp lacZ fragment, followed by polyA signal sequence under the control of the mouse Tek promoter and enhancer. (J:71622)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:71622 Willuweit A, et al., Chronic inflammation and protection from acute hepatitis in transgenic mice expressing TNF in endothelial cells. J Immunol. 2001 Oct 1;167(7):3944-52
• All: 4 reference(s)