Ano1^tm1.1Cahb
Targeted Allele Detail

Summary

• Symbol: Ano1^tm1.1Cahb
• Name: anoctamin 1, calcium activated chloride channel; targeted mutation 1.1, Christian Hubner
• MGI ID: MGI:5588146
• Synonyms: Tmem16a^fl
• Gene: Ano1 Location: Chr7:144142286-144305711 bp, - strand Genetic Position: Chr7, 88.85 cM
• Alliance: Ano1^tm1.1Cahb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207993
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: Exon 21 was floxed. Cre-mediated recombination removed the neomycin resistance cassette inserted upstream of exon 21. (J:207993)

Generation of the Ano1^tm1.1Cahb and Ano1^tm1.2Cahb alleles

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ano1 Mutation: 60 strains or lines available

References

• Original: J:207993 Heinze C, et al., Disruption of vascular Ca2+-activated chloride currents lowers blood pressure. J Clin Invest. 2014 Feb 3;124(2):675-86
• All: 3 reference(s)