Insc^tm1.2Cayo
Targeted Allele Detail

Summary

• Symbol: Insc^tm1.2Cayo
• Name: INSC spindle orientation adaptor protein; targeted mutation 1.2, Michel Cayouette
• MGI ID: MGI:5588153
• Synonyms: mInsc^DEL
• Gene: Insc Location: Chr7:114342931-114449615 bp, + strand Genetic Position: Chr7, 60.23 cM
• Alliance: Insc^tm1.2Cayo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214064
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated excision of 82 kb of sequence beginning after exon 1b and ending after exon 13, just beforethe IRES-tau-EGFP cassette, produced this knockout reporter. Immunohistochemistry for both the long and short isoforms failed to detect protein product in cochlear hair cells of homozygotes. (J:214064)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Insc Mutation: 30 strains or lines available

References

• Original: J:214064 Tarchini B, et al., A molecular blueprint at the apical surface establishes planar asymmetry in cochlear hair cells. Dev Cell. 2013 Oct 14;27(1):88-102
• All: 2 reference(s)