Ido2^tm1.2Gcp
Targeted Allele Detail

Summary

• Symbol: Ido2^tm1.2Gcp
• Name: indoleamine 2,3-dioxygenase 2; targeted mutation 1.2, George C Prendergast
• MGI ID: MGI:5588193
• Gene: Ido2 Location: Chr8:25021908-25066349 bp, - strand Genetic Position: Chr8, 12.58 cM
• Alliance: Ido2^tm1.2Gcp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211949
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into exon 9. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted into exon 10. Flp-mediated recombination removed the selection cassette. The insertion of loxP sites in exons 9 and 10 inserted stop codons resulting in a null allele. Cre-mediated recombination removed exons 9 and 10. Western blot analysis confirmed the absence of protein expression in the liver and kidney. (J:211949)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ido2 Mutation: 42 strains or lines available

References

• Original: J:211949 Metz R, et al., IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation. Int Immunol. 2014 Jul;26(7):357-67
• All: 7 reference(s)