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Hsbp1tm1Miv
Targeted Allele Detail
Summary
Symbol: Hsbp1tm1Miv
Name: heat shock factor binding protein 1; targeted mutation 1, Nahid F Mivechi
MGI ID: MGI:5588201
Gene: Hsbp1  Location: Chr8:120071277-120075668 bp, + strand  Genetic Position: Chr8, 67.54 cM
Alliance: Hsbp1tm1Miv page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:206878
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA portion of exon 1 following the ATG codon, exon 2, and intron 1 were replaced with a cassette containing an EGFP reporter gene, the thymidine kinase promoter with a simian virus 40 polyA signal and a PGK-neomycin gene flanked by two loxP sites, creating an out-of-frame deletion. Western blot confirmed absence of protein expression. EGFP expression is driven by the Hsbp1 promoter and is detected at E0.5 and E1.5 in blastocysts and during later stages (E8.5-10.5) in heterozygotes. (J:206878)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsbp1 Mutation:  8 strains or lines available
References
Original:  J:206878 Eroglu B, et al., An essential role for heat shock transcription factor binding protein 1 (HSBP1) during early embryonic development. Dev Biol. 2014 Feb 15;386(2):448-60
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory