Ppp1r35^{tm1.1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Ppp1r35^{tm1.1(KOMP)Vlcg}
• Name: protein phosphatase 1, regulatory subunit 35; targeted mutation 1.1, Velocigene
• MGI ID: MGI:5588283
• Synonyms: Ppp1r35^-
• Gene: Ppp1r35 Location: Chr5:137777138-137778372 bp, + strand Genetic Position: Chr5, 76.7 cM
• Alliance: Ppp1r35^{tm1.1(KOMP)Vlcg} page
• IMPC: Ppp1r35 gene page

Ppp1r35^{tm1.1(KOMP)Vlcg}/Ppp1r35^{tm1.1(KOMP)Vlcg} embryos exhibit embryonic lethality, with the normal number of embryos at E7.5-E9.5 but failure to turn. Embryos show developmental delay, ballooning pericardial sac and neural tube cell death.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: 14018A-G3
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: Cre-mediated excision of the parental Ppp1r35^{tm1(KOMP)Vlcg} allele resulted in the removal of the neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Expression

In Mice Carrying this Mutation:	129 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppp1r35 Mutation: 11 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 6 reference(s)