Atp8a2^tm1Rsmy
Targeted Allele Detail

Summary

• Symbol: Atp8a2^tm1Rsmy
• Name: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2; targeted mutation 1, Robert S Molday
• MGI ID: MGI:5588356
• Gene: Atp8a2 Location: Chr14:59884980-60324363 bp, - strand Genetic Position: Chr14, 31.49 cM
• Alliance: Atp8a2^tm1Rsmy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211318
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 12 and 13, which encode transmembrane segment M4 and part of the P-domain of P-type ATPases. Western blot analysis confirmed the absence of protein expression in the retina. (J:211318)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp8a2 Mutation: 74 strains or lines available

References

• Original: J:211318 Coleman JA, et al., Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival. J Cell Sci. 2014 Mar 1;127(Pt 5):1138-49
• All: 3 reference(s)