Zc3h12d^tm1Tom
Targeted Allele Detail

Summary

• Symbol: Zc3h12d^tm1Tom
• Name: zinc finger CCCH type containing 12D; targeted mutation 1, Toshimitsu Matsui
• MGI ID: MGI:5588370
• Synonyms: TFL^-, Zc3h12d^tm1Ttmt
• Gene: Zc3h12d Location: Chr10:7708234-7746160 bp, + strand Genetic Position: Chr10, 2.44 cM
• Alliance: Zc3h12d^tm1Tom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209383
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 2. Western blot analysis confirmed the absence of protein expression in the brain, thymus and spleen. (J:209383)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zc3h12d Mutation: 30 strains or lines available

References

• Original: J:209383 Minagawa K, et al., Posttranscriptional modulation of cytokine production in T cells for the regulation of excessive inflammation by TFL. J Immunol. 2014 Feb 15;192(4):1512-24
• All: 3 reference(s)