Rr32^tm1.1Weav
Targeted Allele Detail

Summary

• Symbol: Rr32^tm1.1Weav
• Name: regulatory region 32; targeted mutation 1.1, Casey Weaver
• MGI ID: MGI:5588381
• Synonyms: Ifng.CNS-22^-
• Gene: Rr32 Location: Chr10:118255061-118255451 bp Genetic Position: Chr10, Syntenic
• Alliance: Rr32^tm1.1Weav page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208819
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Modified regulatory region, Null/knockout) Mutations: Insertion, Intergenic deletion Mutation details: A loxP site was inserted upstream of the 391 bp conserved noncoding sequence located 22 kb upstream and regulating expression of Ifng (CNS-22). An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of the sequence. Cre-mediated recombination removed the regulatory sequence. (J:208819)

Generation of the Rr32^tm1.1Weav allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr32 Mutation: 0 strains or lines available

References

• Original: J:208819 Balasubramani A, et al., Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription. PLoS Genet. 2014 Jan;10(1):e1003969
• All: 1 reference(s)