Akap6^tm1.1Mskf
Targeted Allele Detail

Summary

• Symbol: Akap6^tm1.1Mskf
• Name: A kinase anchor protein 6; targeted mutation 1.1, Michael S Kapiloff
• MGI ID: MGI:5588705
• Synonyms: mAKAP^fl
• Gene: Akap6 Location: Chr12:52746166-53202382 bp, + strand Genetic Position: Chr12, 22.18 cM
• Alliance: Akap6^tm1.1Mskf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214288
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector contains a FRT-flanked neomycin cassette followed by a loxP site upstream exon 9 and loxP downstream of exon 9. Flpe mediated recombination removed the FRT-flanked neo cassette leaving exon 9 floxed. (J:214288)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Akap6 Mutation: 113 strains or lines available

References

• Original: J:214288 Kritzer MD, et al., The scaffold protein muscle A-kinase anchoring protein beta orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure. Circ Heart Fail. 2014 Jul;7(4):663-72
• All: 2 reference(s)