Smc5^{tm1b(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Smc5^{tm1b(KOMP)Wtsi}
• Name: structural maintenance of chromosomes 5; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:5602831
• Gene: Smc5 Location: Chr19:23183815-23251261 bp, - strand Genetic Position: Chr19, 18.04 cM
• Alliance: Smc5^{tm1b(KOMP)Wtsi} page
• IMPC: Smc5 gene page

Mutation origin

• Mutant Cell Line: EPD0395_1_F05
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: Cre-mediated recombination of the parental Smc5^{tm1a(KOMP)Wtsi} allele resulted in the removal of the promoter-driven neomycin selection cassette and exon 4, leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smc5 Mutation: 42 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 4 reference(s)