Adamts9^tm1.2Apte
Targeted Allele Detail

Summary

• Symbol: Adamts9^tm1.2Apte
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 9; targeted mutation 1.2, Suneel Apte
• MGI ID: MGI:5603304
• Synonyms: Adamts9^del
• Gene: Adamts9 Location: Chr6:92749680-92920473 bp, - strand Genetic Position: Chr6, 41.41 cM
• Alliance: Adamts9^tm1.2Apte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213412
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to insert a loxP- and FRT-flanked neomycin resistance (neo) cassette upstream of exon 5, and a second loxP site downstream of exon 8. FLPe-mediated recombination removed the FRT-flanked cassette leaving exons 5 through 8 floxed. Cre-mediated recombination removed exons 5 through 8. Exons 5 through 8 encode a substantial portion of the catalytic domain of the gene. (J:213412)

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adamts9 Mutation: 90 strains or lines available

References

• Original: J:213412 Dubail J, et al., A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression. Genesis. 2014 Jul;52(7):702-12
• All: 4 reference(s)