Lyn^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Lyn^M1Btlr
• Name: LYN proto-oncogene, Src family tyrosine kinase; mutation 1, Bruce Beutler
• MGI ID: MGI:5603319
• Synonyms: Lemon
• Gene: Lyn Location: Chr4:3676865-3791613 bp, + strand Genetic Position: Chr4, 2.05 cM
• Alliance: Lyn^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: The Lemon mutation is an A to G transition at base pair 3,746,768 (Build 38) on Chromosome 4, which is base pair 68,648 of the genomic region containing Lyn (GenBank NC_000070). The mutation, in the seventh of the gene's 13 exons, corresponds to nucleotide (nt) 794 of the mRNA sequence (NM_001111096) encoding the long isoform of the LYN protein (Lynp56) and to nt 731 of the transcript (NM_010747) encoding the short protein isoform (Lynp53). Alternative splicing of exon 2 produces mRNAs encoding the two protein isoforms, which differ at their amino (N) termini; Lynp56 is 21 amino acids longer than Lynp53. The Lemon mutation results in a histidine (H) to arginine (R) substitution at position 182 (H182R) in the Lynp56 (ENSMUSP00000038838) isoform and at position 162 (H162R) in the Lynp53 (ENSMUSP00000100075) isoform. (J:214511)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lyn Mutation: 65 strains or lines available

References

• Original: J:214511 Choi JH, et al., Mutagenetix entry for Lemon. Updated on October 29, 2014. MGI Direct Data Submission. 2014
• All: 1 reference(s)