Mrpl22tm1b(KOMP)Mbp
Targeted Allele Detail
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Symbol: |
Mrpl22tm1b(KOMP)Mbp |
Name: |
mitochondrial ribosomal protein L22; targeted mutation 1b, Mouse Biology Program, UC Davis |
MGI ID: |
MGI:5603347 |
Synonyms: |
Mrpl22- |
Gene: |
Mrpl22 Location: Chr11:58062487-58070391 bp, + strand Genetic Position: Chr11, 35.89 cM
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Alliance: |
Mrpl22tm1b(KOMP)Mbp page
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IMPC: |
Mrpl22 gene page |
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Mrpl22tm1b(KOMP)Mbp/Mrpl22tm1b(KOMP)Mbp mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.
Show the 1 phenotype image(s) involving this allele.
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Mutant Cell Line: |
DEPD0007_6_E07 |
Germline Transmission: |
Earliest citation of germline transmission:
J:204739
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Parent Cell Line: |
JM8A1.N3 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
Vector: L1L2_Bact_P
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Mutation details: Cre-mediated excision of the parental Mrpl22tm1a(KOMP)Mbp allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
(J:204739)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023; |
All: |
5 reference(s) |
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