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Akap6tm1.2Mskf
Targeted Allele Detail
Summary
Symbol: Akap6tm1.2Mskf
Name: A kinase anchor protein 6; targeted mutation 1.2, Michael S Kapiloff
MGI ID: MGI:5603562
Gene: Akap6  Location: Chr12:52746166-53202382 bp, + strand  Genetic Position: Chr12, 22.18 cM
Alliance: Akap6tm1.2Mskf page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:214288
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe targeting vector contains a FRT-flanked neomycin cassette followed by a loxP site upstream exon 9 and loxP downstream of exon 9. Flpe mediated recombination removed the FRT-flanked neo cassette leaving exon 9 floxed. Cre mediated recombination removed exon 9. (J:214288)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akap6 Mutation:  113 strains or lines available
References
Original:  J:214288 Kritzer MD, et al., The scaffold protein muscle A-kinase anchoring protein beta orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure. Circ Heart Fail. 2014 Jul;7(4):663-72
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory