Yap1^{tm1c(KOMP)Mbp}
Targeted Allele Detail

Summary

• Symbol: Yap1^{tm1c(KOMP)Mbp}
• Name: yes-associated protein 1; targeted mutation 1c, Mouse Biology Program, UC Davis
• MGI ID: MGI:5603606
• Synonyms: Yap1^flox, Yap1 floxed
• Gene: Yap1 Location: Chr9:7932000-8004597 bp, - strand Genetic Position: Chr9, 2.46 cM
• Alliance: Yap1^{tm1c(KOMP)Mbp} page
• IMPC: Yap1 gene page

Mutation origin

• Mutant Cell Line: DEPD00520_3_E08
• Germline Transmission: Earliest citation of germline transmission: J:228499
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: This conditional allele, in which exon 1 is flanked by loxP sequences, was derived from Yap1^{tm1a(KOMP)Mbp} by flp recombinase-mediated excision of the lacZ reporter and the neomycin resistance cassette. Cre recombinase expression will result in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:157064)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Yap1 Mutation: 38 strains or lines available

References

• Original: J:228499 Nishio M, et al., Dysregulated YAP1/TAZ and TGF-beta signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E71-80
• All: 21 reference(s)