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Tg(MMTV-Akt1)1173Stma
Transgene Detail
Summary
Symbol: Tg(MMTV-Akt1)1173Stma
Name: transgene insertion 1173, Steven M Anderson
MGI ID: MGI:5603751
Synonyms: MMTV-myrAkt1
Transgene: Tg(MMTV-Akt1)1173Stma  Location: unknown  
Alliance: Tg(MMTV-Akt1)1173Stma page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Constitutively active, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThis transgene expresses a constitutively active mutant of Akt in the mammary glands of mice under the control of the MMTV promoter, which allows expression of the transgene in the epithelial cells of the mammary gland. The active mutant of Akt (myr-Akt) used in these studies contains an amino-terminal myristoylation sequence from c-src fused to the coding sequence of Akt1. This directs the fusion protein to the plasma membrane where it can be constitutively activated after phosphorylation of Thr308 and Ser473. A hemagglutinin (HA) epitope tag at the carboxyl-terminal end of the protein was also included to allow for detection of expression by immunoblotting. In addition to line 1173, the lower expressing line 1176 was also created. (J:69612)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:69612 Schwertfeger KL, et al., Mammary gland involution is delayed by activated Akt in transgenic mice. Mol Endocrinol. 2001 Jun;15(6):867-81
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory